All of my builds are for funsies; obviously just play Squirrel Girl, Magik, Nick Fury, or whatever character is buffed too much on CoA next if you want to have no trouble with any content whatsoever.

I setup my ability keybinds between left and right mouse as ASDQWE; movement always on D, signature always on Q. Since it's CoA I hold down left click and spam A+S while peppering in QWE in that order as cds come up. Right click is usually situational/spender ability I can either spam or use instead of left click.