I used fabiobr's Sweet Christmas guide and updated with Max Infinity and a few gearing tweaks with some more gear options below:

Luke Cage is a Bruiser archetype which means he benefits from Durability and Fighting so we want to prioritize those attributes over any others.

It's a convenient archetype because Durability gives Health and Defense while Fighting gives Critical Hit Rating and reduces Melee damage. We will be stacking Fighting over Durability because of the Crit Hit Rating but both give flat 4% damage per point so if you want a little more beefiness, feel free to get some more Durability.

 

Rotation is 

 for vulnerability,  for combo points, hold down  to fill up combo points,  for huge numbers,  for AoE,  which resets all your cooldowns, and then  with all your buffs. Then you will be filling up combo points and rotating between the 2 finishers until your Signature comes back up.

 

 will whiff sometimes even when it feels like you're right on top of the enemy which holds Luke back from being a top-tier hero. But it's very satisfying to hit 3 brutes in the millions of damage when it works correctly.

 

Luke really thrives in single target damage and not so much in AoE clearing so I prefer to live in Patrol zones with him and leave terminal bounties to other heroes.

 

He's not a great summoner so I would stick to melee damage and treat his summons as just a nice to have.

 

Slot 1 Options

 - BiS in my opinion. Luke can be a little squishy so I like the rez and the extra health 

 - These are also pretty great, big damage. 

- Lots of damage as well with some attack speed.

 

Slot 2 Options

 - Great survivability, good for damage.

 - This is usable if you want the rez. We don't need the power duration much though. 

 

Slot 3 Options

 - A lot of survivability with big attribute boost and some damage.

 - Strong back-up with a lot of boost to your survivability.

 

Slot 4 Options

 - Decent boots with boosts to health and damage.

Cosmic Boots - I think it would be hard to beat Luke's boots but I'm keeping my eye out for +4 Fighting, CHR, CDR with Cosmic Might to experiment with for the additional health and CDR.

  - Also a decent option with a good balance of stats.

 

Slot 5 Options

 - These are pretty great with Health, Damage, CHR, and CDR.

 - Strong slot 5 contender that has more damage mitigation than the shades if you're trying to be bulkier.

  - An old chase item that works well for Luke and can be fun to play with. 

 

Artifact Options

 - Great artifact option. Flat damage, BSR, Shield.

 - Durability gives damage, health, and defense. Also has flat damage and BDR. Vehicular Manslaughter is ranged for the occasional knockdown proc.

 - Gives Durability, Strength, and Fighting. Also pumps up brutes and adds a little health regen for good measure.

 - Great damage artifact. Flat damage, CHR, BSR, and tasty BDR.

 - Big DPS loss but adds a lot of health. Can be a nice filler as you gear up and build your IP.

 - Balanced defensive/offensive artifact. 

 - Damage focused artifact that adds Fighting, flat damage, CDR, BDR, and attack speed.

 - Defensive artifact that weakens enemies around you.

 - Adds Fighting, flat damage, and some mitigation with deflect. Also summons Elektra on Sig use.

 

While you're leveling or building out your artifact stash prioritize anything with damage, crits, brutes, Durability, Fighting, physical damage, health.

 

Medallion Options

 - Great stats for us. Fighting, health, CHR, CDR and flat damage.

 - Easier to get ahold of and gives us a lot of damage, BSR, and BDR with a little extra regen.

 - Defense focused Medallion if you're trying to get beefier.

 - Adds some survivability and a little damage.

 - Good offense and survivability.

  

Runeword Options

  - Brut Damage on this is excellent.

 - Cheap placeholder runeword to keep you upright.

 - Placeholder that's a little better and less cheap.

 - Placeholder that adds a little to offense and defense.

 

Ring Options

 - Physical sling ring gives a ton of survivability along with some damage.

 - ICP physical ring is a solid choice as well.

 

Legendary Options

 - ilvl 80 BiS choice

 - ilvl 70 choice

 

Insignia Options

 - This is my favorite but really any insignia with Crit Damage Rating and then either CHR, BSR, BDR to go along with it.