This is a no-signature build for those who find it underwhelming like I do

Rotation: Hold down  (spender) with left mouse button to target lock, , ,,  and when off cooldown. Use  only when above 75% symbiotic armor (spirit). Use medkit off cooldown for +100 symbiotic armor (spirit), assuming you have that affix on 

Replacements

No  (for vulnerability) or  variant: Replace   with  , replace talent row 1 "no pain no reign" (no. 3) with "cautious carnage" (no. 2)

Signature variant:  Use  as spender, swap  and  out for  and weave  by tapping it once every second. Replace 's cosmic affix with -10% signature reduction

• Team-up: Replace Agent Coulson with Jessica Jones or Pirate Deadpool (free through quest) for more defence
• Replace 1000 damage on signature use for your  cosmic affix with 50% damage shield on medkit use
• Replace  for  ,  for  (more offensive) or  (more defensive), odin's blessing mix (hela, volstagg, sif, odin) for  if you keep dying
• Replace  with  if you do not have the former
• Replace with  (any 2 of the following affixes: CDR/BDR/dura/str) if you do not have the former
• His own uniques are fine if you do not have any of the former uniques