This is a work in progress.

I've been playing with something a bit unorthodox lately with having Tanya and MOTG.

While it is essentially double dipping with the Weakness I'm interested in the damage to Weakened enemies for both items which give me roughly 1200DR to all enemies since the weaken is permanent and effects all nearby enemies.
The weaken of course effectively gives me better defence as well and the bubble proc on Tanya's I've tried to balance defence and damage as much as possible.

The slow also helps keep enemies in place while I'm zipping around.

I'm not sure why but on this site my Damage reduction is showing lower than it is in game which is at 44% with no buffs.