Change Log:
June 15th, 2017: TTK update, infinity redistribution
April 13th, 2017: Infinity points, swapped to a different layout
March 31st, 2017: Infnity Points update
February 27th, 2017 - Skill changes, thanks to mikwuyma.
February 26th, 2017 - Patch 2.04 Stuff

Will try to keep this updated as much as my Iron Man guide.

~ SingAlongWithTsing

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Why didn't you choose a talen in row 4? Column 1 removes a dot which sucks, Knockdown sweep's base damage needs a buff plus I was getting sick of it bugging out and not working, Close Combat mines only does half the damage (losing 5s really hurts).

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Build Goal
Aim for balance between TTK and TTL. 
TTK 1 min 43s, Patch 2.1 - June 15th, 2017

1369 Infinity, TU- Synergy 130%, Ult lv 20. I honestly still prefer to play with Sling-Ring and Gravity Well (at least enough to get the 50+ Space Mastery Bonus) but hey what the hell, this is for the CTTK curious.

TTK 1 min 47s, Patch 2.08 - April 14th with 21 Int from Mind Gem 

0:09 ~ 1:56 TU Syngergy 120%, 1158 Infinity

TTK 1 min 50s, Patch 2.08  - April 14th, Gravity Well / Farm Spec

0:08 ~ 1:58 TU Syngergy 120%, 1158 Infinity, this is with 150 points (+75% Base HP) in Gravity Well in the Space Gem

TTK 1 min 55s, Patch 2.08 - April 13th

0:09 ~ 2:04 TU Syngergy 120%, 1150 Infinity, with Sling Ring


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Blessing Choices
Either Hogun or Hela depending on how close you are to 45% Brute chance.

Blessing

 * 4
1200 Melee DR
800 Brute Strike * 0.8 = 640
Approximate DR Value: 1840

 * 4 
1600 Brute Strike * 0.8 = 1280
1600 Brute Damage * 0.24 = 384
Approximate DR Value: 1664

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Attack Speed Note
I've only chosen to get Predator's Frenzy's APS to 3.5 after the bleed proc. I'm not sure if going beyond that is necessary or if the amount I have now is too much.

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Cosmic Artifacts Affixes
The 4 I would choose are:
+1 to all Attributes
10% Signature cooldown Reduction
2000 HP
1500 Defense (BP is a Dodge Deflect character, round out your eHP with Defense, less diminishing returns) or regenerate 150 HP per Second. 15% Spirit Cost Reduction is also an excellent choice, you would be ablt to take some points out of Calculated Efficiency for more points into Intellegence.

Artifacts


500 DR
4 Int = 640 DR
200 Crit Rating * 1.42 = 284
200 Brute Rating * 0.8 = 160
240 Crit Damage Rating * 0.55 = 132
Approximate DR Value: 1716


150 DR
3 INT = 480
252 Crit Rating * 1.42 = 357.84
253 Brute Rating * 0.8 = 202.4
180 Crit Damage * 0.55 = 99
586 Brute Damage * 3 stacks  * 0.24 = 421.92 
Approximate DR Value: 1705.92

 Cosmic
200 Melee Damage 
+1 All Attributes (in our case we''ll be using INT/Fighting) = 320
250 Crit Rating * 1.42 = 355
350 Brute Rating * 0.8 = 280
60 Crit Damage * 0.55 = 33
586 Brute Damage * 3 stacks  * 0.24 = 421.92 
Approximate DR Value: 1642.92
It's a bit lower in raw damage but the access to a Cosmic Affix improves the overall damage of  the kit.


300 DR
3 Fighting = 480 DR
800 Crit Damage * 0.55 = 440
800 Brute Damage * 24 = 192
5.8 Attack Speed = 191.4
Approximate DR Value: 1603.4


505 Melee DR
421 DR
468 Crit Rating * 1.42 = 664.56
Approximate DR Value: 1590.56


375 Crit Rating * 1.42 = 532.5
375 Brute Rating * 0.8 = 300
900 Crit Damage * 0.55 = 495
900 Brute Damage * 0.24 = 216
Approximate DR Value: 1543.5


1 Int = 160
1 Energy = 160
250 DR
250 Crit Rating = 355
250 Brute Rating = 200
760 Crit Damage = 418
Approximate DR Value: 1543


600 DR
538 Crit Rating * 1.42 = 763.96
Approximate DR Value: 1363.96
Can replace any of the above if you need more TTL

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Unique (Slot 1)
WIP

Unique (Slot 2)
WIP

Unique (Slot 3)
WIP

Unique (Slot 4)


321 DR x 3 stacks = 963
4 Fighting (3 Base + 1 from proc) = 640
3 INT = 480
180 Crit Damage (from 3 INT) * 0.55 = 99
8% Attack speed * 33 = 264
Approximate DR Value: 2446, 2768 if tagged as a Movement Power.
Attack Speed subject to heavy Diminishing Returns.

 (Feb 23rd, 2017)
2 Int = 320 Damage
349 Crit Rating * 1.42 = 495.58
2327 Crit Damage Rating * 0.55 = 1279.85
349 Brute Strike * 0.8 = 279.2
Approximate DR Value: 2374.63


482 DR from Proc 
2 Fighting = 320
2 INT = 320
120 Crit Damage * 0.55 = 66
618 Brute Strike * 0.8 = 494.4
2070 Brute Damage * 0.24 = 496.8
Approximate DR Value: 2179.2

Unique (Slot 5)
WIP

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Legendary


1400 Physical DR
700 Crit * 1.42 = 994 
700 Brute Strike * 0.8 = 560 
1400 Brute Damage * 0.24 = 336
Approximate DR Value: 3290 if Physical


1500 DR
1000 Crit * 1.42 DR per Crit = 1420 DR
Approximate DR Value: 2920 
Norn Stones may be better than Savage Axe due to points  in Potency (+X% Damage to Sig) from the Power Gem.


1500 Melee DR
750 Crit * 1.42 = 1065
Approximate DR Value: 2565

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Team Ups

 Raids / TTK Testing

 I use Jessica for almost all content. Taunt, Bleed, Weakens, and Vaccums up enemies.